N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Patients With Schizophrenia
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چکیده
منابع مشابه
The Role of N-acetylaspartylglutamate (naag) in the Amygdala
Endogenously released dipeptide N-acetylaspartylglutamate (NAAG) is efficacious in animal models of several clinical disorders including inflammatory and neuropathic pain. NAAG peptidase inhibitors prolong the dipeptide’s level and function at the synapse. NAAG mediates its analgesic effect by dampening release of neurotransmitter glutamate through activation of presynaptic group II metabotropi...
متن کاملDifferential distribution of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat forebrain.
Contradictory immunohistochemical data have been reported on the localization of N-acetylaspartylglutamate in the rat forebrain, using different carbodiimide fixation protocols and antibody purification methods. In one case, N-acetylaspartylglutamate immunoreactivity was observed in apparent interneurons throughout all allocortical and isocortical regions, suggesting possible colocalization wit...
متن کاملRegulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators.
The neuronal dipeptide N-acetylaspartylglutamate (NAAG) is thought to be synthesized enzymatically from N-acetylaspartate (NAA) and glutamate. We used radiolabeled precursors to examine NAA and NAAG biosynthesis in SH-SY5Y human neuroblastoma cells stimulated with activators of protein kinase A (dbcAMP; N6,2'-O-dibutyryl cAMP) and protein kinase C (PMA; phorbol-12-myristate-13-acetate). Differe...
متن کاملIntracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain
BACKGROUND The peptide neurotransmitter N-Acetylaspartylglutamate (NAAG) is the third most prevalent transmitter in the mammalian central nervous system. Local, intrathecal and systemic administration of inhibitors of enzymes that inactivate NAAG decrease responses to inflammatory pain in rat models. Consistent with NAAG's activation of group II metabotropic glutamate receptors, this analgesia ...
متن کاملSynthesis and release of N-acetylaspartylglutamate (NAAG) by crayfish nerve fibers: implications for axon-glia signaling.
Early physiological and pharmacological studies of crayfish and squid giant nerve fibers suggested that glutamate released from the axon during action potential generation initiates metabolic and electrical responses of periaxonal glia. However, more recent investigations in our laboratories suggest that N-acetylaspartylglutamate (NAAG) may be the released agent active at the glial cell membran...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2011
ISSN: 1745-1701,0586-7614
DOI: 10.1093/schbul/sbr127